Complex Regional Pain Syndrome
What is it?
What is it?
- A neuropathic painful syndrome with time-dependent regional inflammation and mixed, central and peripheral sensibilization
- The International Association for the Study of Pain (IASP) defined CRPS as “a syndrome that usually develops after a noxious event, is not limited to the distribution of a single peripheral nerve, and is apparently disproportionate to the initiating event”
- Trauma
- Fractures
- Surgical
- Infection
- inflammation
- Autonomic and trophic disorders
- Edema
- Skin temperature changes
- Redness
- Sweating
- Atrophy
- Sensory
- Glove and stocking distribution
- Spontaneous pain – burning, dragging, or stinging
- Sensory gain or sensory loss
- Motor dysfunction
- Weakness
- Difficulty with complex movements
- Range of motion deficits
- Neglect
- Tremors
- Dystonia – especially in CRPS-II
- Local pain
- Physical exam
- History of trauma
- Sensory issues
- Edema
- Redness
- Females more than males
- Genetic predisposition
- All ages, but mostly 50-70 years old
- Mainly, Caucasian and Japanese
- Can happen in any body part, but wrists are most frequent